Multicomponent synthesis of 4-unsubstituted 5-nitropyridine derivatives Full article
| Journal |
Synthetic Communications
ISSN: 0039-7911 , E-ISSN: 1532-2432 |
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| Output data | Year: 2020, Volume: 50, Number: 16, Pages: 2432-2439 Pages count : 8 DOI: 10.1080/00397911.2020.1780261 | ||||
| Tags | Green chemistry, 5-nitro-1,4-dihydropyridines, 5-nitropyridines, multicomponent reaction | ||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Russian Foundation for Basic Research | 19-03-00376 |
Abstract:
Multicomponent reaction of 2-nitroacetophenone, urotropine (or paraformaldehyde), β-dicarbonyl compound and ammonium acetate afforded five new 4-unsubstituted 5-nitro-6-phenyl-1,4-dihydropyridine derivatives, oxidation of which provided the corresponding 5-nitro-6-phenylpyridines. The proposed approach for the synthesis of 4-unsubstituted 5-nitro-6-phenyl-1,4-dihydropyridines and their subsequent aromatization into pyridines made it possible to reduce the total reaction time by more than 200 times and the overall yield of 5-nitro-6-phenylpyridine by 2 times compared with the known methods.
Cite:
Kulakov I.V.
, Oleshchuk A.L.
, Koveza V.A.
, Palamarchuk I.V.
Multicomponent synthesis of 4-unsubstituted 5-nitropyridine derivatives
Synthetic Communications. 2020. V.50. N16. P.2432-2439. DOI: 10.1080/00397911.2020.1780261 WOS Scopus РИНЦ OpenAlex
Multicomponent synthesis of 4-unsubstituted 5-nitropyridine derivatives
Synthetic Communications. 2020. V.50. N16. P.2432-2439. DOI: 10.1080/00397911.2020.1780261 WOS Scopus РИНЦ OpenAlex
Dates:
| Submitted: | Dec 22, 2019 |
| Published online: | Jun 23, 2020 |
| Published print: | Aug 17, 2020 |
Identifiers:
| Web of science: | WOS:000547312400001 |
| Scopus: | 2-s2.0-85087375165 |
| Elibrary: | 45496904 |
| OpenAlex: | W3036963612 |