Butyric acid and prospects for creation of new medicines based on its derivatives: a literature review

Butyric acid and prospects for creation of new medicines based on its derivatives: a literature review Review

Journal

Journal of Veterinary Science
ISSN: 1229-845X

Output data

Year: 2024, Volume: 25, Number: 2, Pages: 1-15 Pages count : 15 DOI: 10.4142/jvs.23230

Tags

Butyric acid; sodium butyrate; butyrates; animal husbandry

Authors

Gerunova Lyudmila K. ¹ , Gerunov Taras V. ¹ , P’yanova Lydia G. ² , Lavrenov Alexander V. ² , Sedanova Anna V. ² , Delyagina Maria S. ² , Fedorov Yuri N. ³ , Kornienko Natalia V. ² , Kryuchek Yana O. ¹ , Tarasenko Anna A. ¹

Affiliations

1	Omsk State Agrarian University named after P. A. Stolypin
2	Center of New Chemical Technologies BIC
3	All-Russian Research and Technological Institute of Biological Industry

The widespread use of antimicrobials causes antibiotic resistance in bacteria. The use of butyric acid and its derivatives is an alternative tactic. This review summarizes the literature on the role of butyric acid in the body and provides further prospects for the clinical use of its derivatives and delivery methods to the animal body. Thus far, there is evidence confirming the vital role of butyric acid in the body and the effectiveness of its derivatives when used as animal medicines and growth stimulants. Butyric acid salts stimulate immunomodulatory activity by reducing microbial colonization of the intestine and suppressing inflammation. Extraintestinal effects occur against the background of hemoglobinopathy, hypercholesterolemia, insulin resistance, and cerebral ischemia. Butyric acid derivatives inhibit histone deacetylase. Aberrant histone deacetylase activity is associated with the development of certain types of cancer in humans. Feed additives containing butyric acid salts or tributyrin are used widely in animal husbandry. They improve the functional status of the intestine and accelerate animal growth and development. On the other hand, high concentrations of butyric acid stimulate the apoptosis of epithelial cells and disrupt the intestinal barrier function. This review highlights the biological activity and the mechanism of action of butyric acid, its salts, and esters, revealing their role in the treatment of various animal and human diseases. This paper also discussed the possibility of using butyric acid and its derivatives as surface modifiers of enterosorbents to obtain new drugs with bifunctional action.

Gerunova L.K. , Gerunov T.V. , P’yanova L.G. , Lavrenov A.V. , Sedanova A.V. , Delyagina M.S. , Fedorov Y.N. , Kornienko N.V. , Kryuchek Y.O. , Tarasenko A.A.
Butyric acid and prospects for creation of new medicines based on its derivatives: a literature review
Journal of Veterinary Science. 2024. V.25. N2. P.1-15. DOI: 10.4142/jvs.23230 WOS Scopus РИНЦ OpenAlex

Submitted:	Sep 15, 2023
Accepted:	Jan 22, 2024
Published online:	Mar 4, 2024

Web of science:	WOS:001196963800005
Scopus:	2-s2.0-85190078154
Elibrary:	66645732
OpenAlex:	W4392733019

DB	Citing
Elibrary	1