Abstract: Objective To improve the management of patients with chronic endometritis (CE) by using a molded sorbent-modified by polyvinylpyrrolidone (FSMP). Methods This prospective study included 70 patients with CE divided into two groups: group 1 (n = 23) received traditional antibiotic therapy (from days 3 to 10 of the menstrual cycle); group 2 (n = 47), received antibiotics and FSMP was inserted from days 5 to 10. Results At the end of therapy, group 1 had massive growth of pathogenic microflora in 21.7%, moderate growth in 69.6%, and no growth in 8.7% of cases. In group 2, after combined therapy, massive growth was observed in 4.3%, moderate growth in 44.7%, and no growth in 51.0%. In group 2 after 5 days, serum levels of interleukin-1 beta (IL-1 beta) were 1.9 times, of IL-6 were 7.0 times, and of IL-8 and IL-1 receptor antagonist were 1.3 times lower than in group 1. In uterine cavity aspirates, IL-1 beta decreased around 4.8 times, IL-6 by 11.8 times, IL-8 by 3.2 times, tumor necrosis factor-alpha by 3.9 times, and IL-1 receptor antagonist by 2.1 times in comparison to group 1. Conclusion Combined therapy of FSMP with antibiotics is more effective in treating CE, because it contributes to the almost complete elimination of pathogens and toxins from the uterine cavity, blocking the local pro-inflammatory cascade.

Cite: Barinov S.V. , Tirskaya Y.I. , Borisova A.V. , Pyanova L.G. , Di Renzo G.C.
The effectiveness of using a molded sorbent: Modified polyvinylpyrrolidone for the combined treatment of chronic endometritis
International Journal of Gynecology & Obstetrics. 2021. DOI: 10.1002/ijgo.13609 WOS Scopus РИНЦ OpenAlex

Dates:

Published online:	Feb 11, 2021
Published print:	Aug 1, 2021

Identifiers:

Web of science:	WOS:000616813500001
Scopus:	2-s2.0-85101050145
Elibrary:	46535033
OpenAlex:	W3125054916

Citing:

DB	Citing
Web of science	1
Scopus	1
OpenAlex	1

Altmetrics: