Multicomponent synthesis of unsymmetrical 5-nitropyridines

Multicomponent synthesis of unsymmetrical 5-nitropyridines Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353

Output data

Year: 2018, Volume: 54, Number: 12, Pages: 1127-1130 Pages count : 4 DOI: 10.1007/s10593-019-02403-x

Tags

5-nitro-1,4-dihydropyridines, 5(3)-nitropyridines, green chemistry, multicomponent reaction

Authors

Koveza Vladislav A. ¹ , Kulakov Ivan V. ^2,3 , Shulgau Zarina T. ³ , Seilkhanov Tulegen M. ⁴

Affiliations

1	F. M. Dostoevskii Omsk State University
2	Institute of Chemistry, Tyumen State University
3	Republican State Enterprise ''National Center for Biotechnology'' under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan
4	Sh. Ualikhanov Kokshetau State University

Reaction of 2-nitroacetophenone, furfurol, β-dicarbonyl compounds, and ammonium acetate led to 3-substituted 4-(2-furyl)-5-nitro6-phenyl-1,4-dihydropyridines, which were oxidized with potassium nitrate in the presence of copper(II) nitrate (10 mol %), leading to the respective 5-nitro-6-phenylpyridines. The performed multicomponent reactions met the general principles of green chemistry. Synthesis of these unsymmetrical 5-nitro-6-phenylpyridines via the formation of 1,4-dihydropyridine intermediates under the conditions of multicomponent reaction significantly shortened the overall reaction time, decreased the number of steps, and improved the yield.

Koveza V.A. , Kulakov I.V. , Shulgau Z.T. , Seilkhanov T.M.
Multicomponent synthesis of unsymmetrical 5-nitropyridines
Chemistry of Heterocyclic Compounds. 2018. V.54. N12. P.1127-1130. DOI: 10.1007/s10593-019-02403-x WOS Scopus РИНЦ OpenAlex

Ковеза В.А. , Кулаков И.В. , Шульгау З.Т. , Сейлханов Т.М.
Многокомпонентный синтез несимметричных 5-нитропиридинов
Химия гетероциклических соединений. 2018. Т.54. №12. С.1127-1130.

Accepted:	Nov 15, 2018
Published print:	Dec 1, 2018
Published online:	Jan 17, 2019

Web of science:	WOS:000461553300007
Scopus:	2-s2.0-85060223021
Elibrary:	38681467
OpenAlex:	W2908699996

DB	Citing
Scopus	9
Web of science	6
OpenAlex	10